Heat-shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells Running title: Enhancement of TCR-mediated apoptosis by Hsp70
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Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells.
DNA fragmentation is a hallmark of cells undergoing apoptosis and is mediated mainly by the caspase-activated DNase (CAD or DNA-fragmentation factor 40 [DFF40]), which is activated when released from its inhibitor protein (ICAD or DFF45) upon apoptosis signals. Here we analyzed the effect of heat shock protein 70 (Hsp70) on CAD activity in T-cell receptor (TCR)-induced apoptosis using a T-cell ...
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تاریخ انتشار 2003